I've talked to VW guys (that do CAR motors) and they don't recommend going that large due to reliability issues. Note that those are near 2300cc displacement- a stock motor is 1600cc. Per the guys I have been talking to (that do cars, not aircraft) the largest they would consider due to issue with stud placement vs. bore for the cylinders is in the 1900 cc range for a reliable motor. For the larger bore sizes, the opening for the cylinder gets too close to the location of the studs, making the case prone to cracking around the studs and pulling out, even with "case savers" installed. Larger strokes run into clearance issues, having to modify (and thus weaken) the case for clearance on the crank throws and counterweights. I would be very cautious with this.
Brad